Medina has exhibited his work both nationally and internationally. He often incorporates a variety of media into his artwork but has an affinity for hot glue and relief printing. His artwork is influenced by Mexican folklore, Texas history, urban legends, cryptozoology, quantum physics, religious iconography, cultural traditions, science fiction, comic books, “gangsta” rap, breakfast tacos and drunken story-telling. One of his best-known accomplishments, a collaboration with San Anto Cultural Arts, was the completion of the world’s first stereoscopic 3-D mural entitled, Vision del Futuro. Located in downtown San Antonio, this large-scale mural project, funded by the National Endowment for the Arts, features an innovative painting technique that is enhanced by the use of 3-D glasses.