Pick of the Litter tails (pun definitely intended) a litter of puppies from the moment they’re born and begin their quest to become guide dogs for the blind. Cameras follow these pups through an intense, two-year odyssey as they train to become dogs whose ultimate responsibility is to protect their blind partners from harm. Along the way, these remarkable animals rely on a community of dedicated individuals who train them to do amazing, life-changing things in the service of their human. The stakes are high and not every dog can make the cut — only the best of the best make it, the “pick of the litter.”