Set in a seedy Oklahoma City motel room, Bug centers on the meeting between Agnes, a divorced waitress with a fondness for cocaine and isolation, and Peter, a soft-spoken Gulf War drifter introduced to her by her friend, R.C. Agnes stays at a hotel in hopes of avoiding her abusive ex, Jerry, who was just released from prison. There’s a hidden bug infestation problem that has both Agnes and Peter dealing with scathing welts and festering sores—which has Peter believing this is the result of experiments conducted on him during his stay at an army hospital. Their fears soon escalate to paranoia, conspiracy theories and twisted psychological motives.